ESR-4 Chun Liu
Università di Bologna, Italy
Characterizing exposure‐PKPD‐biomarker relationships in special patient populations
Antimicrobial stewardship programs are gaining more and more relevance in optimizing anti-infective treatment and in preventing emergence of antimicrobial resistance. Personalization of antimicrobial treatment based on real-time TDM and dosing adaptation may represent an important tool in antimicrobial stewardship programs. In this ESR/PhD project we aim to focus on differences in pharmacokinetics (PK) for meropenem and piperacillin/tazobactam and host response biomarkers in severe Gram‐negative related infections occurring in special patient populations (e.g., geriatric, hemato‐oncology). We are interested in identifying optimized model‐based individualized dosing strategies for these antibiotics focusing on biomarker‐guided prediction of PK parameters using population PK modelling. We expect to identify optimal model‐based dosing targets for these antibiotics for special patient populations for implementation in TDM routines, and mathematical models characterizing the relationship between biomarkers and outcomes in these populations.
Supervisors: Federico Pea, Elisabetta Poluzzi
Interests and Hobbies: Movie, Cats