The Innovative Training Network (ITN) Training towards Innovative Personalized Antibiotic Therapy (TIPAT) has started March 1, 2020. TIPAT offers a cutting-edge training-by-research program for 15 Early Stage Researchers (ESRs) / PhD candidates. TIPAT is part of the Marie Skłodowska-Curie International Training Network (ITN) of the European Commission. ESRs in TIPAT are part of an international network of universities, hospitals and companies. The duration of all ESR positions is 36 or 48 months depending on the host institute, and should lead to a PhD degree.
To enable development of innovative personalized antibiotic treatment strategies, quantitative understanding of the interplay between drug, pathogen and host is crucial. The TIPAT network will train inter-disciplinary specialists optimally equipped with a skill set to address this challenge.
Central to the TIPAT research and training program of ESRs is the combination of state-of-the art quantitative modelling with approaches in clinical pharmacology, immunology and microbiology, which enables development of innovative methodology to personalized antibiotic therapies. The main goals of TIPAT are:
- characterize the effect of host (patient)‐associated factors impacting antibiotic (target‐site) exposure
- quantify the effect of antibiotic exposure on pathogen‐specific killing, resistance and tolerance
- define relationships between host immune response, bacterial infection, and antibiotic therapy
- provide cross‐discipline training in (i) the scientific areas of microbiology, clinical pharmacology, immunology, and quantitative modelling, (ii) regulatory and entrepreneurial competences, and iii) transferable skills