ESR-10 Raphaël Saporta

Uppsala Universitet, Sweden

Model-based translation of antibiotics-bacteria-neutrophil interactions in vivo

The overall aim of this project is to design experiments for studies of PKPD-relationships for antibiotics in presence of different levels of immune response and develop pharmacometric models that quantitatively characterize the pathogen-neutrophil interaction, in the presence of different dosages of antibiotics, as well as to develop an innovative model-based methodology for translation of preclinical PKPD to clinical antibiotic effects, for different infection types.

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Supervisors: Lena Friberg, Elisabet Nielsen

Interests and hobbies: Video editing, esports, computer sciences, board games