ESR-1 Maria Sanz Codina
Medizinische Universität Wien, Austria
Host factors predicting target site penetration of antibiotics in difficult to treat patient populations
This clinically orientated PhD will set out to optimize antimicrobial therapy based on personalized medicine to determine optimal individualized dosing strategies. In order to combat a bacteria pathogen, an antibiotic must reach the site of infection. Determination of the concentration at the infection site is challenging for individual patients, but various biomarkers might predict target site concentration. The applicant will perform studies in healthy volunteers and patients to predict the unbound plasma to tissue distribution of at least four antibiotics for severe gram‐negative infections using micro‐dialysis and bronchoalveolar lavage and mathematical PBPK modelling.
These biomarkers shall be further validated and ultimately combined in a model and clinical scoring system predicting tissue/plasma ratio of drug exposure in patients with systemic critical infections. To achieve this goal a combination of clinical skills, pathophysiological processes, and basics mathematical modelling will be acquired or improved.
Supervisors: Assoc. Prof. Priv.-Doz. Dr. Markus Zeitlinger
Interests: I am interested in tackling the development of innovative personalized antibiotic treatment strategies since infectious diseases are becoming increasingly challenging.